Intramuscular Injectables


Intramuscular Injectables

At Novus Medical Detox Center, we strive to provide the best, safest, easiest and most comfortable withdrawal from drugs and alcohol.  We provide our patients:

  • A home-like setting;
  • Private or comfortable shared rooms;
  • 24/7 medical attention;
  • Detox programs designed specifically for each patient;
  • Delicious food;
  • 3.25 treed acres;
  • Television with DVD player and internet access in every room;
  • Staff who care about you and your progress.

Unlike many other detox facilities, at Novus we pay particular attention to strengththening our patient’s bodies so that their detox programs will go smoother, but also so that when they leave Novus they will be better able to handle their next step--rehab or just going home.  We know that our patients do better when:

  • They are properly hydrated;
  • The needed vitamin and mineral deficiencies are handled;
  • They receive additional GABA;
  • They receive additional glutathione (a natural and very effective antioxidant).

ADMINISTRATION, ABSORPTION, BIOAVAILABILITY AND THE BLOOD-BRAIN BARRIER

Identifying the various things that a person needs in order to more easily withdraw is an essential element of treatment.  However, the next step is providing these things to the person in the most effective way.  The first consideration is the administration of the needed items.

ADMINISTRATION

The most common ways that substances can enter the body and be absorbed are:

  • Orally
  • Inhaled
  • Intramuscular (a shot in a muscle)
  • Subcutaneous (an injection just under the skin)
  • Intravenous (through a vein--IV)
  • Transdermal (administered through the skin like a skin patch or cream)
  • Rectally

DRUG ABSORPTION AND BIOAVAILABILITY

Once a substance has been administered, then it has to be absorbed by the body in order for it to be used.  There are a number of factors that determine the absorption, but a primary one is bioavailability.  Bioavailability is a term used to indicate how much of a substance actually is available for the body to use.  For example, if a vitamin tablet is taken orally, it will be absorbed from the stomach and intestine and will pass through the liver to be metabolized before it gets in the bloodstream.  During this process, some or most of the actual needed ingredients in the vitamin tablet are lost and are never available to the body.  This translates into lower bioavailability. In fact, some vitamin tablets are so resistant to being broken down into their active ingredients that they will pass through the body and be excreted as intact tablets. Even when the tablet is dissolved, it is estimated that many people only absorb a small percentage of the content of the tablet.  Obviously, in this case the bioavailability is even lower. Another example is the way that the body metabolizes Suboxone when it is taken orally.  Suboxone contains buprenorphine, which is an opioid receptor stimulator, and naloxone, which is an opioid receptor blocker.  If a Suboxone tablet is taken under the tongue (sublingually), then the body will absorb mostly the buprenorphine and not the naloxone.  If the Suboxone pill is crushed and snorted or injected, the body will absorb mostly the naloxone and this will cause uncomfortable opioid withdrawal symptoms.  This quality is why Suboxone has been approved for use in opioid detox programs. However, if a substance goes directly into the bloodstream, like from an IV, it will likely have high bioavailability.  If a substance is injected in the muscle, the bioavailability is lower than with the IV but much higher than would be obtained from the same amount of substance administered in other ways.

THE BLOOD BRAIN BARRIER

Drugs intended to affect the central nervous system must penetrate the blood-brain barrier.  This is a system of tightly woven capillaries that protect the brain from unwanted substances—such as viruses.  If a substance cannot penetrate the blood-brain barrier then it will not be of much use. 

GABA

We have found that giving GABA (Gamma-Amino Butyric acid) to our patients really assists them during their detox.  GABA is the major inhibitory neurotransmitter in the brain.  When things seem to be going too fast, GABA slows them back down.  GABA receptors are the areas of the brain which benzodiazepines like Xanax and Valium stimulate to produce their sedating effects.  (You can read more about GABA here.)   

GABA cannot just be taken orally.  The medical literature is pretty clear that there is little chance that GABA taken orally will penetrate the blood-brain barrier.  However, there is evidence that GABA administered through an IV or intramuscular injection will penetrate the blood-brain barrier.  Our patients receiving IV's with GABA report that it definitely has a calming effect and helps them be more relaxed and also sleep.

GLUTATHIONE

Glutathione is another substance that we find is very helpful to our patients during their medical detox. Found in almost every cell, glutathione is the major antioxidant produced by the cells.  An oxidant is a substance that "strips" an electron from an atom and, if not stopped, will damage or destroy essential parts of the cell.  These stripped atoms are called free radicals and can be created by a number of things such as pollutants and toxins.  In addition to acting as an antioxidant, glutathione is effective in keeping other antioxidants such as vitamin C and vitamin E active in the body, helps the body get rid of toxins and pollutants, and is very important to the proper operation of the body's immune system. Like GABA, it is very difficult to administer glutathione in a way that can be effectively absorbed by the body.  At Novus, we administer it through an IV.  This method of administration and intramuscular injections are thought to be the best way to get the maximum amount of glutathione used by the body.

THE NOVUS IV'S

The most effective and most rapid method of administration for almost every substance is directly into the bloodstream with an IV.  This will ensure that the vitamins, minerals, electrolytes, glutathione, GABA and saline solution are rapidly absorbed and used by the body.  Our patients tell us how much better they feel after they start receiving the Novus IV's.  Of note is that some of these patients have been to previous detox facilities before.  They indicate that the other facilities did not pay attention to hydration or use IV's, and that they felt better much more quickly at Novus.  This is not just due to the IV's, but is significant anecdotal evidence that our protocols, including the IV's, are unique and very workable.

 

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INTRAMUSCULAR INJECTED VITAMINS

Dr. Brent Agin, the Novus medical director, has developed intramuscular vitamins, minerals and amino acids that can provide many of the benefits of the Novus IV's but can be done at home.  These intramuscular ("IM") preparations are commonly injected into the large muscle in the buttocks.  Dr. Agin also offers GABA and glutathione IM injections. 

While these IM injections are very good for Novus patients to take home, they are also even more important for someone who is attempting to detox from drugs on their own or in an outpatient facility.

CONCLUSION Drugs and alcohol create changes in the body.  Abuse of these substances will create damaging changes.  Obviously, if the body is in better health, it will respond more efficiently to correcting these changes.  If the body is dehydrated, depleted in vitamins and minerals and deficient in needed amino acids, then a drug or alcohol withdrawal will be much more difficult.  Helping the body regain this health and be a positive factor in drug or alcohol withdrawal is the purpose of our Novus protocols and is the purpose of the Novus IV's and IM vitamins and amino acids.  These two items are a part of what makes Novus so unique.

At Novus Medical Detox Center, we specialize in helping people find a cure to the problems caused by drugs and alcohol.  People also come to us for a safe and more comfortable:

Please contact us if we can help someone that you know.

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NOTE: This information is provided for general educational purposes only and is not intended to constitute (i) medical advice or counseling, (ii) the practice of medicine, health care diagnosis or treatment, or (iii) the creation of a physician patient or clinical relationship.  If you have or suspect that you have a medical problem or that this information may be useful to you or others, please consult with your health care provider before applying any information from our articles to your personal situation or to the personal situation of others.

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Novus Medical Detox Center can safely and more comfortably help you through your drug detox program.

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